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The dangerous side of popular sleep and anxiety drugs like Xanax and Lorazepam

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If you’ve been HBO’s new season of White Lotus, then you’ve seen Parker Posey’s character Victoria Ratliff popping a steady stream of Lorazepam while on a family vacation at a Thailand wellness resort, at one point comically declaring, “Someone stole my Lorazepam. I’m going to have to drink myself to sleep.” 

The drug, also known under the brand name Ativan, is part of a class called benzodiazepines, which also includes Xanax and Klonopin. Only available through prescription, they are used to help relieve anxiety and muscle spasms, and reduce seizures, according to the DEA. However, as seen in the show, they can lead to dependence and overuse. 

“We definitely see that a lot in real life as well,” Dr. Ian Neel, a geriatrician at UC San Diego Health, tells the New York Times about the class of drugs.

Of the over 30 million adults who reported using benzodiazepines in the last year, over 5 million misused them (described as “any way a doctor did not direct”), per 2019 data from the National Survey on Drug Use and Health

While some people may have taken a one-time Xanax to calm flight anxiety, for example, long-term use is what poses the most danger as it can lead to dependence. People can become dependent even when taking the prescribed amount, Dr. Ludmila De Faria, chair of the American Psychiatric Association’s council on women’s mental health, told the New York Times. 

Particularly important is the appeal of “benzos” to older adults: Those ages 50 to 64 are the biggest consumers of this class of drugs, according to the 2019 study, and need to use extra caution due to the drugs’ potential effects on slowing cognition.

The class of drugs slows down the nervous system and often takes an immediate effect. And while they are generally safe when taken as prescribed for a limited time, side effects include drowsiness, memory problems, and slurred speech. Overuse can cause worsened effects, including dependence, cognitive impairment, coma, and potential death, although rare. 

Neel cautioned that older adults may metabolize drugs differently, and should be aware of the potential for negative interactions with other medications and drugs they might be taking. Combining benzodiazepines with other depressants like alcohol, for example, can exacerbate feelings of sedation, as seen on White Lotus, as Posey’s character usually pops Lorazepam with a glass of wine. 

When regular users of benzodiazepines—often called benzos—try to wean off the drugs, it’s common to experience withdrawal symptoms, like sweating, headaches, and heart palpitations according to the American Addiction Centers

“Each benzodiazepine medication has a specific half-life that influences the length of time it takes for the drug to leave the bloodstream,” according to the Center. “If an individual is dependent on a benzo, once the drug is purged from the body, withdrawal may begin.” 

It’s important to talk to a medical doctor and a mental health professional if you think you’re experiencing any withdrawal symptoms or negative side effects from benzodiazepines because there are other ways to treat anxiety and sleep orders. “The first-line treatment [for anxiety] is typically antidepressants like SSRIs [antidepressants], plus psychotherapy,” Dr. David Merrill, a geriatric psychiatrist at Providence Saint John’s Health Center in Santa Monica, Calif. told Healthline.

For more on sleep, mental health, and more:

This story was originally featured on Fortune.com

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Americans see growing risk they’ll get turned down for loans

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A growing share of US consumers say they’re not seeking loans because they expect to be refused amid tight credit conditions, according to data from the Federal Reserve Bank of New York. 

The share of discouraged borrowers, defined as respondents who said they needed credit but didn’t apply because they didn’t expect to get approved, climbed to 8.5% in the New York Fed’s latest Survey of Consumer Expectations. That’s the highest level since the study began in 2013.

The perceived likelihood of being rejected increased across different forms of credit, from cards to secured loans to buy homes and cars. Roughly one-third of auto loan applicants expected to get turned down, the highest share since the start of the series, while nearly half of all respondents in the February survey said it’ll be harder to get credit in a year’s time.

The data adds to a picture of increasingly fragile household finances for many Americans, as a cooling job market slows wage gains while high borrowing costs are making bills harder to pay. Delinquency rates remain low by pre-pandemic standards but they’ve been edging higher in most categories, and lenders are turning cautious.  

More than four in 10 US homeowners who sought to refinance their mortgages had their applications rejected, according to the February survey, quadruple the share in October 2023. 

With mortgage lending rates still much higher than a couple of years ago, many people seeking a refi are likely trying to tap equity accumulated during the recent housing boom in order to meet other debt costs or expenses, rather than to reduce their monthly payments. Inability to do so could put some under pressure to sell their homes. 

Meanwhile, the share of consumers in the New York Fed survey who said they could come up with $2,000 in the event of an unexpected need declined to 63%, a new series low.

This story was originally featured on Fortune.com

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Jet maker Bombardier warns Canada that F-35 review may backfire

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The head of Canadian jet manufacturer Bombardier Inc. raised concerns about Canada’s decision to review a contract to buy dozens of F-35 fighter jets from Lockheed Martin Corp., the country’s latest response to the trade war with the US.

“Canceling the F-35s might be a good idea, but we need to think about it,” Bombardier Chief Executive Officer Eric Martel told a business audience in Montreal. “We have contracts with the Pentagon. Will there be reciprocity there?” 

Bombardier has invested in recent years in its defense unit, which converts jets into military aircraft. It has two contracts with the US government, one for communication aircraft and another for surveillance planes.

New Canadian Prime Minister Mark Carney ordered a review of the F-35 purchase agreement, a C$19 billion ($13.3 billion) deal for 88 jets that was finalized in 2023. The deal hasn’t been scrapped, but the government needs to “make sure that the contract in its current form is in the best interests of Canadians and the Canadian Armed Forces,” a defense ministry spokesperson said. 

Earlier this month, President Donald Trump put 25% tariffs on imports on Canadian goods that don’t fall under the US–Mexico–Canada Agreement, and added 25% import taxes to aluminum and steel products. He has repeatedly said he believes Canada should be the 51st US state — a recent poll showed that 90% of Canadians disagree — and members of his administration have taken the Canadian government to task for its low level of military spending. 

“Trump isn’t wrong on everything,” Martel said. “We’ve been hiding behind our big brother for a while, and we’re completely dependent on him militarily.”

In 2023, Canada finalized a deal to order as many as 16 military surveillance aircraft from Boeing Co. as part of an investment worth more than $7 billion, rejecting a competing Bombardier proposal.

The jet maker’s shares have dropped 18% since Trump was elected on Nov. 5, but are still up about 50% over the past year. 

In February, Bombardier set aside its financial outlook for the year because of risk and uncertainty about tariffs. “Not providing guidance is the most responsible thing for us to do,” Martel said at the time. About 60% of Bombardier’s business comes from the US, and its planes are currently built and shipped under the rules of the US-Mexico-Canada Agreement. 

Bombardier has a complicated supply chain that includes manufacturing in US and Mexico with more than 2,800 US-based suppliers across 47 states. US-made parts and systems make up a significant proportion of the cost of its aircraft. 

The Global 7500, the firm’s flagship jet, has wings made in Texas, avionics from Iowa and motors made in Indiana. More than half of its building costs are tied to US manufacturing, but the assembly and finishing are done in Canada, which makes the jet subject to tariffs.

Two-thirds of Canada’s aerospace industry exports depend on the US market, Martel said.

This story was originally featured on Fortune.com

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Gavin Newsom is welcoming prominent conservatives on his new podcast, but critics say it’s risky to align himself ‘in a slightly unpredictable middle’

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LOS ANGELES (AP) — As a wounded Democratic Party struggles to regroup, California Gov. Gavin Newsom is holding mostly chummy conversations with prominent conservatives on a new podcast he’s touting as a way for the party to grapple with the MAGA movement’s popularity.

In doing so, he appears intent on showing he is more than a progressive warrior. But he has stunned some members of his own party by agreeing with his guests on issues such as restricting transgender women and girls in sports. Newsom called dismantling police departments “lunacy” and remained silent when Steve Bannon, an architect of President Donald Trump’s 2016 campaign, falsely said Trump won the 2020 presidential election.

The programs provide a fresh lens on a liberal governor and potential 2028 presidential candidate who not long ago was enlisted as a chief surrogate for President Joe Biden’s campaign. Ahead of the 2022 midterms, he chastised national Democrats for being too passive in defending abortion rights and same-sex marriage, an issue he championed two decades ago as mayor of San Francisco.

Newsom said his choice of podcast guests reflects his interest in knowing more about how Republicans organized in the last election, when Trump swept every battleground state and Republicans locked up majorities in the House and Senate.

“I think we all agreed after the last election that it’s important for Democrats to explore new and unique ways of talking to people,” he added in an email to supporters.

Newsom’s party criticizes his guests

After spotlighting Bannon, conservative radio personality Michael Savage and Turning Point USA founder Charlie Kirk, Newsom will quickly diversify his lineup: His next guest is Minnesota Gov. Tim Walz, last year’s Democratic vice presidential nominee. But some Democrats say the governor, who is widely viewed as having presidential ambitions, is selling out Democratic values in favor of his own political aspirations.

Aimee Allison, the founder and president of She the People, a national organizing hub for electing women of color, said Newsom is betraying California and “showing his weakness and naked ambition.” Allison was among Democrats who helped Newsom defeat a 2021 recall attempt.

“We need a governor that will defend California’s values, support vulnerable children, LGBTQ+ people, Black people, women, and everyone else who’s in the line (of) fire of the Trump administration. Instead he is making the worst moves possible in a time of rising fascism. He’s trying to remake himself to be acceptable to MAGA,” Allison wrote in an email, referring to supporters of Trump’s “Make America Great Again” movement.

California Assembly member Chris Ward and state Sen. Carolina Menjivar, who lead the state’s LGBTQ+ legislative caucus, said they were “profoundly sickened” by Newsom’s statement on transgender athletes. And Kentucky Gov. Andy Beshear, another potential 2028 candidate, said of Bannon, “I don’t think we should give him oxygen on any platform — ever, anywhere.”

Finding a new audience

Podcasts have become an increasingly important venue in politics, and as Newsom considers a national campaign he has been praised by some for venturing into unfamiliar territory.

Democratic consultant Bill Burton, who was national press secretary for former President Barack Obama’s 2008 campaign, credited Newsom with trying to reach voters who might not engage with traditional media.

“I think there are going to be a lot of people this alienates in the short term,” Burton said. But, he added, Democrats “have to take a lot of big swings.”

The governor — who called Trump a threat to American democracy throughout last year’s campaign — has been trying to navigate a tenuous relationship with the White House as the state recovers from the devastating Los Angeles wildfires in January. He’s requested $40 billion in federal aid.

Newsom, while progressive, has never been locked into one ideological position: He’s broken at times with more liberal factions in the Legislature. His shift this time may be to head off the kind of criticism Republicans have aimed at former Vice President Kamala Harris, also of California, or edge toward positions more closely in line with public opinion. According to AP VoteCast, 55% of voters nationwide in the 2024 election said support for transgender rights in government and society has gone too far.

During the podcast episodes released so far, Newsom has been mostly affable and agreeable, though he’s challenged his guests at times. This is not the tart-tongued Newsom who appeared in a 2023 televised debate with Republican Florida Gov. Ron DeSantis, whom he described as weak and pathetic, or who called the state legislature into special session last year to attempt to safeguard the state’s progressive policies under a Trump administration.

In an age of rigid partisanship, talking with the other side is “so rarely a part of public discourse it seems like either bravery or lunacy,” said Thad Kousser, a political science professor at the University of California, San Diego. “While there are clear risks, he is trying to align his national reputation … in a slightly unpredictable middle.”

This story was originally featured on Fortune.com

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